50-1505 Datasheet, PDF (2/6 Pages) List of Unclassifed Manufacturers – Flexible PCB

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The #1 drawback of using polyimide-based flex in a design you are wanting to do is flat-out
availability! The #2 drawback is COST!
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There is even a third disadvantage to using polyimide film
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All things being equal, there really is only one problem using 1-ply fiberglass. It tends to "snap"